Where is actin located in the body

Transcriptome analysis and classification of genes into tissue distribution categories Figure 8 shows that genes encoding proteins that localize to actin filaments and focal adhesion sites are more likely to be expressed in many tissues, but less likely to be detected in all tissues, compared to all genes presented in the Cell Atlas.

Thus, these genes tend to show a somewhat more restricted pattern of tissue expression. Figure 8. Bar plot showing the percentage of genes in different tissue distribution categories for actin filaments-associated protein-coding genes compared to all genes in the Cell Atlas.

Parikh K et al. Cell Res. Nat Methods. J Proteomics. J Proteome Res. Alberts B et al, Molecular Biology of the Cell. New York: Garland Science. Actin Filament Assembly. Accessed November 25, We use cookies to enhance the usability of our website.

If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again. Search Fields » Search result. Gene name. Class Biological process Molecular function Disease. External id. Reliability Enhanced Supported Approved Uncertain.

Reliability Supported Approved. Validation Supported Approved Uncertain. Annotation Intracellular and membrane Secreted - unknown location Secreted in brain Secreted in female reproductive system Secreted in male reproductive system Secreted in other tissues Secreted to blood Secreted to digestive system Secreted to extracellular matrix. Searches Enhanced Supported Approved Uncertain Intensity variation Spatial variation Cell cycle intensity correlation Cell cycle spatial correlation Cell cycle biologically Custom data cell cycle dependant Cell cycle dependent protein Cell cycle independent protein Cell cycle dependent transcript Cell cycle independent transcript Multilocalizing Localizing 1 Localizing 2 Localizing 3 Localizing 4 Localizing 5 Localizing 6 Main location Additional location.

Type Protein Rna. Phase G1 S G2 M. Cell type. Expression Not detected Low Medium High. Cell type Any Alveolar cells type 1 Alveolar cells type 2 B-cells Basal glandular cells Basal keratinocytes Bipolar cells Cardiomyocytes Cholangiocytes Ciliated cells Club cells Collecting duct cells Cone photoreceptor cells Cytotrophoblasts Distal tubular cells Ductal cells Early spermatids Endothelial cells Enterocytes Erythroid cells Exocrine glandular cells Extravillous trophoblasts Fibroblasts Glandular cells Granulocytes Hepatocytes Hofbauer cells Horizontal cells Intestinal endocrine cells Ito cells Kupffer cells Late spermatids Leydig cells Macrophages Melanocytes Monocytes Mucus-secreting cells Muller glia cells Pancreatic endocrine cells Paneth cells Peritubular cells Proximal tubular cells Rod photoreceptor cells Sertoli cells Smooth muscle cells Spermatocytes Spermatogonia Suprabasal keratinocytes Syncytiotrophoblasts T-cells Undifferentiated cells Urothelial cells.

Category Cell type enriched Group enriched Cell type enhanced Low cell type specificity Not detected Detected in all Detected in many Detected in some Detected in single Is highest expressed.

Category Cell line enriched Group enriched Cell line enhanced Low cell line specificity Not detected Detected in all Detected in many Detected in some Detected in single Is highest expressed. Category Lineage enriched Group enriched Lineage enhanced Low lineage specificity Not detected Detected in all Detected in many Detected in single Is highest expressed.

Clermont 26 : 27— Google Scholar. Bretscher, A. USA 78 : — Bryan, J. Cachon, J. DeRosier, D. CrossRef Google Scholar. Egelman, E. A38 : — Barden, eds. Flock, A. Gillis, J. Hanson, J. Hartwig, J. Huxley, H. Kane, R. Korn, E. PubMed Google Scholar. Moore, P. Cytoskeletal filaments provide the basis for cell movement. For instance, cilia and eukaryotic flagella move as a result of microtubules sliding along each other.

In fact, cross sections of these tail-like cellular extensions show organized arrays of microtubules. Other cell movements, such as the pinching off of the cell membrane in the final step of cell division also known as cytokinesis are produced by the contractile capacity of actin filament networks. Actin filaments are extremely dynamic and can rapidly form and disassemble. In fact, this dynamic action underlies the crawling behavior of cells such as amoebae.

At the leading edge of a moving cell, actin filaments are rapidly polymerizing; at its rear edge, they are quickly depolymerizing Figure 5. A large number of other proteins participate in actin assembly and disassembly as well.

Figure 5: Cell migration is dependent on different actin filament structures. These protrusive structures contain actin filaments, with elongating barbed ends orientated toward the plasma membrane. B During cellular arm extension, the plasma membrane sticks to the surface at the leading edge. C Next, the nucleus and the cell body are pushed forward through intracellular contraction forces mediated by stress fibers. D Then, retraction fibers pull the rear of the cell forward.

Filopodia: molecular architecture and cellular functions. Nature Reviews Molecular Cell Biology 9, All rights reserved. Figure Detail. This page appears in the following eBook. Aa Aa Aa. Microtubules and Filaments. What Is the Cytoskeleton Made Of? The cytoskeleton of eukaryotic cells is made of filamentous proteins, and it provides mechanical support to the cell and its cytoplasmic constituents.

All cytoskeletons consist of three major classes of elements that differ in size and in protein composition. Microtubules are the largest type of filament, with a diameter of about 25 nanometers nm , and they are composed of a protein called tubulin. Actin filaments are the smallest type, with a diameter of only about 6 nm, and they are made of a protein called actin.

Intermediate filaments, as their name suggests, are mid-sized, with a diameter of about 10 nm. Unlike actin filaments and microtubules, intermediate filaments are constructed from a number of different subunit proteins. What Do Microtubules Do? Figure 1. What Do Actin Filaments Do? Figure 2. What Do Intermediate Filaments Do? Figure 4: The structure of intermediate filaments.

Intermediate filaments are composed of smaller strands in the shape of rods. How Do Cells Move?