What should be called a lectin nature

Plant lectins: a composite of several distinct families of structurally and evolutionary related proteins with diverse biological roles. Plant Sci. Messages from the past: new insights in plant lectin evolution. Isolation and characterization of a lectin with exclusive specificity towards mannose from snowdrop Galanthus nivalis bulbs. FEBS Lett. Related mannose-specific lectins from different species of the family Amaryllidaceae.

Leaves of the orchid twayblade Listera ovata contain a mannose-specific lectin. Developmental changes and tissue distribution of lectin in Tulipa. New mannose-specific lectins from garlic Allium sativum and ramsons Allium ursinum bulbs. Carbohydrate Res. The major tuber storage protein of Araceae species is a lectin: Characterization and molecular cloning of the lectin from Arum maculatum L. Isolation, characterization, molecular cloning and molecular modelling of two lectins of different specificities from bluebell Scilla campanulata bulbs.

Binding properties of a mannose-specific lectin from the snowdrop Galanthus nivalis bulb. Kaku, H. Peumans, W. Shannon and M. Chrispeels, eds. Van Damme, E. Characterization of the proteins and the cDNA clones. The seed lectins of black locust Robinia pseudoacacia are encoded by two genes which differ from the bark lectin genes. Plant Mol. A structural basis for the difference in specificity between the two jacalin-related lectins from mulberry Morus nigra bark.

A novel lectin Morniga M from mulberry Morus nigra bark recognizes oligomannosyl residues in N -glycans. The Urtica dioica agglutinin is a complex mixture of isolectins. Isolation of a novel plant lectin with an unusual specificity from Calystegia sepium. Glycoconjugate J. Isolectins in Narcissus : complexity, inter- and intraspecies differences and developmental control. Characterization of Urtica dioica agglutinin isolectins and the encoding gene family.

Isolation and characterization of a jacalin-related mannose-binding lectin from salt-stressed rice Oryza sativa plants. Trends Plant Sci. The galactose-binding and mannose-binding jacalin-related lectins are located in different subcellular compartments. Nucleocytoplasmic plant lectins.

Plant lectins. ISBN 0——X N-linked sugar-regulated protein folding and quality control in the ER. Cell Dev. UniLectin3D, a database of carbohydrate binding proteins with curated information on 3D structures and interacting ligands. Nucleic Acids Res. Rini JM. Lectin structure. Structure of mannose-specific snowdrop Galanthus nivalis lectin is representative of a new plant lectin family. Nat Struct. Hester, G. Structure analysis of refined complexes at 2.

Structure-function relationship of monocot mannose-binding lectins. Mannose-binding plant lectins: different structural scaffolds for a common sugar-recognition process. Overview of the structure-function relationships of mannose-specific lectins from plants, algae and fungi. Legume lectin structure. Bourne, Y. Barre, A. Artocarpin is a polyspecific jacalin-related lectin with a monosaccharide preference for mannose.

Structural analysis of the polyspecific jacalin-related lectin MornigaM from the black mulberry Morus nigra in complex with mannose. FEBS J. Analytical Application of Lectins. Affinity enhancement by multivalent lectin-carbohydrate interaction. Multivalent lectin-carbohydrate interactions energetics and mechanisms of binding. Wu, Springer, pp. The tobacco lectin, prototype of the family of Nictaba-related proteins. Higher plants developed structurally different motifs to recognize foreign glycans.

Trends Glycosci. Surya, P. Sukumaran, S. Genome-wide identification and domain organization of lectin domains in cucumber. Distribution and evolution of the lectin family in soybean Glycine max Molecules. Saeed, B. Plant Genome 9 [ PubMed ]. Eggermont, L. Plant Genome 10 [ PubMed ].

Comparative study of lectin domains in model species: New insights into evolutionary dynamics. Signaling through plant lectins: modulation of plant immunity and beyond.

In: Glycome: The hidden Code in Biology. Prevalence, biological activity and genetic manipulation of lectins in foods. Trends Food Sci.

Are dietary lectins relevant allergens in plant food allergy? Luo, Y. Food 11 , 43—49 Changes in levels of phytic acid, lectins and oxalates during soaking and cooking of Canadian pulses. Food Res. Plant lectins as defense proteins against phytophagous insects.

Insecticidal activity of plant lectins and potential application in crop protection. Lectins as antimicrobial agents. Lectin domains at the frontiers of plant defense. Legume lectins: proteins with diverse applications. Plant-insect interactions: what can we learn from plant lectins? Insect Biochem. Al Atalah, B. Sadeghi, A. Transgenic Res. Nicotiana tabacum agglutinin is active against Lepidopteran pest insects. Expression of snowdrop lectin in transgenic tobacco plants results in added protection against aphids.

In vitro and in vivo binding of snowdrop Galanthus nivalis agglutinin; GNA and jackbean Canavalia ensiformis ; Con A lectins within tomato moth Lacanobia oleracea larvae; mechanisms of insecticidal action. Insect Physiol. Fusion proteins containing insect-specific toxins as pest control agents: snowdrop lectin delivers fused insecticidal spider venom toxin to insect haemolymph following oral ingestion.

Insecticidal activity of scorpion toxin ButaIT and snowdrop lectin GNA containing fusion proteins towards pest species of different orders. Pest Manag Sci. A fusion protein containing a lepidopteran-specific toxin from the South Indian red scorpion Mesobuthus tamulus and snowdrop lectin shows oral toxicity to target insects. BMC Biotechnol. Bhatti, M. Tariq, M. Biologia 75 , — Expression of hybrid fusion protein Cry1Ac::ASAL in transgenic rice plants imparts resistance against multiple insect pests.

Development of broad-spectrum and sustainable resistance in cotton against major insects through the combination of Bt and plant lectin genes. Plant Cell Rep. Poulsen, M. Distribution of glycan motifs at the surface of midgut cells in the cotton leafworm Spodoptera littoralis demonstrated by lectin binding.

Penetration of peritrophic matrix is a key to lectin toxicity against Tribolium castaneum. Immunohistochemical and developmental studies to elucidate the mechanism of action of the snowdrop lectin on the rice brown planthopper, Nilaparvata lugens Stal J. Effects of antinutrient proteins on Hessian fly Diptera: Cecidomyiidae larvae.

Protein N-glycosylation and N-glycan trimming are required for postembryonic development of the pest beetle Tribolium castaneum. The N-glycome of the hemipteran pest insect Nilaparvata lugens reveals unexpected sex differences. N -glycosylation site analysis reveals sex-related differences in protein N -glycosylation in the rice brown planthopper Nilaparvata lugens Mol. The N-glycan profile of the peritrophic membrane in the Colorado potato beetle larva Leptinotarsa decemlineata J.

Li, W. Genome-wide analysis of lectin receptor-like kinase family from Arabidopsis and rice. Protein-carbohydrate interactions as part of plant defense and animal immunity. Lambin, J. Sun, Y. Rice lectin protein r40c1 imparts drought tolerance by modulating S-adenosylmethionine synthase 2, stress-associated protein 8 and chromatin-associated proteins.

Structures of the complexes of a potent anti-HIV protein cyanovirin-N and high mannose oligosaccharides. Pacak F, Kocourek J. Studies on phytohemagglutinins: XXV. Isolation and characterization of hemagglutinins of the spindle tree seeds Evonymus europaea L. Schmidt VG. The lectin of Euonymus europaeus : purification, characterization, and an immunochemical study of its combining site.

Proteins with an Euonymus lectin—like domain are ubiquitous in Embryophyta. BMC Plant Biol. The carbohydrate-binding promiscuity of Euonymus europaeus lectin is predicted to involve a single binding site. Isolation and characterization of a lectin with exclusive specificity towards mannose from snowdrop Galanthus nivalis bulbs.

FEBS Lett. Structure of mannose-specific snowdrop Galanthus nivalis lectin is representative of a new plant lectin family. Structural basis for chitin recognition by defense proteins: GlcNAc residues are bound in a multivalent fashion by extended binding sites in hevein domains. Structure and function of chitin-binding proteins.

Hevein: NMR assignment and assessment of solution-state folding for the agglutinin-toxin motif. The galactose-binding and mannose-binding jacalin-related lectins are located in different subcellular compartments.

Structural basis for the unusual carbohydrate-binding specificity of jacalin towards galactose and mannose. Cavada, B. Legume lectins: proteins with diverse applications. Conformation, protein-carbohydrate interactions and a novel subunit association in the refined structure of peanut lectin-lactose complex.

The rice LysM receptor-like kinase OsCERK 1 is required for the perception of short-chain chitin oligomers in arbuscular mycorrhizal signaling.

New Phytol. Bateman, A. Kaku, H. OsCERK 1 plays a crucial role in the lipopolysaccharide-induced immune response of rice. Mutational analysis of the carbohydrate binding activity of the tobacco lectin. Ribosome-inactivating proteins from plants. Rutenber, E. Proteins Struct. Printed covalent glycan array for ligand profiling of diverse glycan binding proteins. Oligosaccharide microarrays for high-throughput detection and specificity assignments of carbohydrate-protein interactions.

Evanescent-field fluorescence-assisted lectin microarray: a new strategy for glycan profiling. Frontal affinity chromatography as a tool for elucidation of sugar recognition properties of lectins. Kasai KI. Frontal affinity chromatography FAC : theory and basic aspects. Nakamura-Tsuruta, S. In: Lectins.

Analytical technologies. Elsevier Science BV, pp. Characterization of the carbohydrate binding specificity and kinetic parameters of lectins by using surface plasmon resonance. Comparative studies on lectin—carbohydrate interactions in low and high density homo-and heteroglycoclusters.

Label-free electrochemical impedance spectroscopy biosensor for direct detection of cancer cells based on the interaction between carbohydrate and lectin. Glycoprofiling of cancer biomarkers: label—free electrochemical lectin—based biosensors. Open Chem. Nanoelectronic detection of lectin-carbohydrate interactions using carbon nanotubes. Nano Lett.

Glycan array: a powerful tool for glycomics studies. Expert Review Proteomics. Cummings, R. In: Essentials of Glycobiology, 3rd edition. Cold Spring Harbor Laboratory Press Van Damme, E. Wu, Springer, pp. Romano, P. Structural basis of multivalent binding to wheat germ agglutinin. Eggermont, L. Plant Genome 10 [ PubMed ]. Comparative study of lectin domains in model species: new insights into evolutionary dynamics. Evolutionary history and stress regulation of the lectin superfamily in higher plants.

BMC Evol. Genome-wide identification and domain organization of lectin domains in cucumber. Distribution and evolution of the lectin family in soybean Glycine max Molecules. Saeed, B. Plant Genome 9 [ PubMed ]. Lectin domains at the frontiers of plant defense. Isolation and characterization of a jacalin-related mannose-binding lectin from salt-stressed rice Oryza sativa plants.

A rice jacalin-related mannose-binding lectin gene, OsJRL, enhances Escherichia coli viability under high salinity stress and improves salinity tolerance of rice. OsEUL lectin gene expression in rice: stress regulation, subcellular localization and tissue specificity. Al Atalah, B. Plant Cell. Signaling through plant lectins: modulation of plant immunity and beyond.

Based Complement. Plant lectins as defense proteins against phytophagous insects. Insecticidal activity of plant lectins and potential application in crop protection. Transgenic rice expressing Allium sativum leaf lectin with enhanced resistance against sap—sucking insect pests. Transgenic rice plants expressing the snowdrop lectin gene GNA exhibit high—level resistance to the white backed planthopper Sogatella furcifera Theor. Enhancement of resistance to aphids by introducing the snowdrop lectin gene GNA into maize plants.

Lysin motif—containing proteins LYP4 and LYP6 play dual roles in peptidoglycan and chitin perception in rice innate immunity. Liu W, Wang GL. Plant innate immunity in rice: a defense against pathogen infection. A B-lectin receptor kinase gene conferring rice blast resistance. Plant J. Lectins: an effective tool for screening of potential cancer biomarkers.

Peer J. Plant lectins: potential antineoplastic drugs from bench to clinic. Cancer Lett. Effect of the Synadenium carinatum latex lectin ScLL on Leishmania Leishmania amazonensis infection in murine macrophages. Induction of apoptosis by Polygonatum odoratum lectin and its molecular mechanisms in murine fibrosarcoma L cells. Overview of the structure—function relationships of mannose—specific lectins from plants, algae and fungi. Phaseolus acutifolius lectin fractions exhibit apoptotic effects on colon cancer: preclinical studies using dimethilhydrazine or azoxi-methane as cancer induction agents.

Plant lectins in cancer therapeutics: targeting apoptosis and autophagy-dependent cell death. Plant lectins, from ancient sugar-binding proteins to emerging anti-cancer drugs in apoptosis and autophagy.

Cell Prolif. Hirabayashi J. Lectin—based glycomics: how and when was the technology born? Plant lectins targeting O—glycans at the cell surface as tools for cancer diagnosis, prognosis and therapy. Lectin microarrays: concept, principle and applications. A sunflower lectin with antifungal properties and putative medical mycology applications. Antifungal and antibacterial activities of lectin from the seeds of Archidendron jiringa Nielsen. Food Chem. The juicy sarcotesta of Punica granatum contains a lectin that affects growth, survival as well as adherence and invasive capacities of human pathogenic bacteria.

Lectins as antimicrobial agents. Potential of carbohydrate-binding agents as therapeutics against enveloped viruses. Plant lectins are potent inhibitors of coronaviruses by interfering with two targets in the viral replication cycle. Activity of and effect of subcutaneous treatment with the broad-spectrum antiviral lectin griffithsin in two laboratory rodent models. Agents Chemother. Garrison, A. Schistosoma mansoni : tegumental damage as a consequence of lectin binding.

Hydrogel and membrane scaffold formulations of Frutalin breadfruit lectin within a polysaccharide galactomannan matrix have potential for wound healing. Gornik O, Lauc G. Enzyme linked lectin assay ELLA for direct analysis of transferrin sialylation in serum samples. Visual detection of serum asialohaptoglobin by plasmonic sandwich ELLSA—a new platform for cirrhosis diagnosis.

Lectin-array blotting: profiling protein glycosylation in complex mixtures. ACS Chem. Plasma glycoprotein profiling for colorectal cancer biomarker identification by lectin glycoarray and lectin blot. Proteome Res. Dot by dot: analyzing the glycome using lectin microarrays. Chemistry of natural glycan microarrays. The use of lectin microarray for assessing glycosylation of therapeutic proteins.

Yang Z, Hancock WS. Monitoring glycosylation pattern changes of glycoproteins using multi-lectin affinity chromatography. Roth J. Lectins for histochemical demonstration of glycans. Cell Biol. Electrochemical biosensing strategies to detect serum glycobiomarkers. A rapid, sensitive and selective electrochemical biosensor with concanavalin a for the preemptive detection of norovirus.

Biosensor based on lectin and lipid membranes for detection of serum glycoproteins in infected patients with dengue.

Interaction of the tobacco lectin with histone proteins. Cell cycle—dependent O—GlcNAc modification of tobacco histones and their interaction with the tobacco lectin. Phosphorylation modification of wheat lectin VER2 is associated with vernalization—induced O—GlcNAc signaling and intracellular motility.

Maeda M, Kimura Y. Structural features of free N-glycans occurring in plants and functional features of de-N-glycosylation enzymes, ENGase, and PNGase: the presence of unusual plant complex type N-glycans.

Plant complex type free N-glycans occur in tomato xylem sap. Sugars and plant innate immunity. Lectins: getting familiar with translators of the sugar code.

UniLectin3D, a database of carbohydrate binding proteins with curated information on 3D structures and interacting ligands. Nucleic Acids Res. Structure and engineering of tandem repeat lectins. Other processes that deactivate the compounds are sprouting grains and beans, and mechanically removing the outer hull of beans and wheat grains that contain the most lectins.

There are different types of lectins in different foods, and the reactions people have to them vary widely. It is possible that one who has an underlying digestive sensitivity, such as irritable bowel syndrome, may be more likely to experience negative symptoms from eating lectins and other anti-nutrients. Because the reported symptoms of lectin sensitivity are recognizable with physical discomfort, a reasonable solution may be to eat less of or less often the foods that cause digestive problems.

Lectins can act as an antioxidant , which protects cells from damage caused by free radicals. They also slow down digestion and the absorption of carbohydrates , which may prevent sharp rises in blood sugar and high insulin levels.

Early research is also looking at the use of non-toxic low amounts of certain lectins to help stimulate gut cell growth in patients who are unable to eat for long periods, and in anticancer treatments due to the ability of lectins to cause cancer cell death. In many large population studies, lectin-containing foods like legumes , whole grains , and nuts are associated with lower rates of cardiovascular disease, weight loss, and type 2 diabetes.

Thus, the health benefits of consuming these foods far outweigh the potential harm of lectins in these foods. Are Anti-Nutrients Harmful? The contents of this website are for educational purposes and are not intended to offer personal medical advice. You should seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.

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